Rabbit Polyclonal Antibody to PEG3

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别名:PW1; ZNF904; ZSCAN24; ZKSCAN22
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5′ exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5′ exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.

Description

In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5′ exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5′ exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.

Specification
Aliases	PW1; ZNF904; ZSCAN24; ZKSCAN22
Swissprot	Q9GZU2
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide of human PEG3
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/30-1/150
ELISA	1/5000-1/10000

	The image is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using P12586(PEG3 Antibody) at dilution 1/45. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P12586(PEG3 Antibody) at dilution 1/45. (Original magnification: ×200)