Rabbit Polyclonal Antibody to Phospho-EGFR (Tyr1092)

包装: 1G|100G|500G|1KG|100KG

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别名:EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation.

Description

EGFR is a receptor tyrosine kinase. Receptor for epidermal growth factor (EGF) and related growth factors including TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. . A single-pass transmembrane tyrosine kinase. Ligand binding to this receptor results in receptor dimerization, autophosphorylation (in trans), activation of various downstream signaling molecules and lysosomal degradation.

Specification
Aliases	EGFR; ERBB; ERBB1; HER1; Epidermal growth factor receptor; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
Entrez GeneID	1956
Swissprot	P00533
WB Predicted band size	Calculated MW: 134 kDa; Observed MW: 140-160 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	The antiserum was produced against synthesized peptide derived from human EGFR around the phosphorylation site of Tyr1092. AA range:1061-1110
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ELISA	1/10000

	Western blot analysis of Phospho-EGFR (Tyr1092) in various lysates using Phospho-EGFR (Tyr1092) antibody.
	Western blot analysis of Phospho-EGFR (Tyr1092) in HUVEC lysates treated with EGF, using EGFR (Phospho-Tyr19, 2) antibody. The lane on the right is blocked with the Phospho- peptide.
	Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma, using EGFR (Phospho-Tyr109, 2) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.