Rabbit Polyclonal Antibody to Phospho-Estrogen Receptor alpha (Ser167)

包装: 1G|100G|500G|1KG|100KG

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别名:ESR1; Era; Eralpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites.

Description

ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites.

Specification
Aliases	ESR1; Era; Eralpha; Estrogen receptor; Estradiol receptor; ER-alpha; Estrogen receptor 1; NR3A1; ER; ESR; ESRA; Estrogen receptor alpha
Entrez GeneID	2099
Swissprot	P03372
WB Predicted band size	Calculated MW: 66 kDa; Observed MW: 66 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide of human ESR1
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ICC	1/100-1/200

	Western blot analysis of Phospho-Estrogen Receptor alpha (Ser167) in MCF-7 lysates using Phospho-Estrogen Receptor alpha (Ser167) antibody.
	Immunofluorescence analysis of Phospho-Estrogen Receptor alpha (Ser167) in MCF-7 cells using Estrogen Receptora(Phospho-Ser167) antibody(red).
	Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue using Estrogen Receptora(Phospho-Ser167) antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval. Sample with blocking peptide on the right.