Rabbit Polyclonal Antibody to Phospho-JAK2/3 (Tyr966/939)

包装: 1G|100G|500G|1KG|100KG

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别名:Tyrosine-protein kinase JAK2/JAK3 (EC 2.7.10.2; Janus kinase 2/Janus kinase 3; JAK-2/JAK-3)
应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Description

Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Specification
Aliases	Tyrosine-protein kinase JAK2/JAK3 (EC 2.7.10.2; Janus kinase 2/Janus kinase 3; JAK-2/JAK-3)
Entrez GeneID	3717/3718
Swissprot	O60674/P52333
WB Predicted band size	Calculated MW: 131 kDa; Observed MW: 120-130 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized Phospho peptide derived from human JAK2/3.at AA range: T966
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
ELISA	1/10000

	Western blot analysis of Phospho-JAK2/3 (Tyr966/939) in mouse liver, hela , mouse brain lysates using Phospho-JAK2/3 (Tyr966/939) antibody.
	Western blot analysis of Phospho-JAK2/3 (Tyr966/939) in hela lysates using Phospho-JAK2/3 (Tyr966/939) antibody.