Rabbit Polyclonal Antibody to Phospho-JAK2 (Tyr1007)

包装: 1G|100G|500G|1KG|100KG

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别名:JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Description

Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.

Specification
Aliases	JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
Entrez GeneID	3717
Swissprot	O60674
WB Predicted band size	Calculated MW: 131 kDa; Observed MW: 131 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	The antiserum was produced against synthesized peptide derived from human JAK2 around the phosphorylation site of Tyr1007. AA range:981-1030
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.