Rabbit Polyclonal Antibody to Phospho-kappa Opioid Receptor (Ser369)

包装: 1G|100G|500G|1KG|100KG

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别名:OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1
应用:WB,IHC
反应种属:Mouse,Rat
规格：50μl/100μl

Description
Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins.The three opioid receptor types are highly homologous and belong to the superfamily of G-protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.

Description

Endogenous opioid peptides and opiates, like morphine, transmit their pharmacological effects through membrane bound opioid receptors. Pharmacological studies and molecular cloning have led to the identification of three different types of opioid receptor, mu-type, delta-type and kappa-type, also designated MOR-1, DOR-1 and KOR-1, respectively. MOR-1 is a receptor for beta-endorphin, DOR-1 is a receptor for enkephalins, and KOR-1 is a receptor for dynorphins.The three opioid receptor types are highly homologous and belong to the superfamily of G-protein-coupled receptors. Opioid receptors have been shown to modulate a range of brain functions, including instinctive behavior and emotions. This regulation is thought to involve the inhibition of neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance.

Specification
Aliases	OPRK1; OPRK; Kappa-type opioid receptor; K-OR-1; KOR-1
Entrez GeneID	4986
Swissprot	P41145
WB Predicted band size	Calculated MW: 43 kDa; Observed MW: 43 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Mouse,Rat
Immunogen	The antiserum was produced against synthesized peptide derived from KOR-1 around the phosphorylation site of Ser369. AA range:331-380
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ELISA	1/10000

	Western blot analysis of Phospho-kappa Opioid Receptor (Ser369) in various lysates using Phospho-kappa Opioid Receptor (Ser369) antibody.
	Western blot analysis of Phospho-kappa Opioid Receptor (Ser369) in rat kidney lysates using Phospho-KOR1 (S369) antibody.
	Western blot analysis of Phospho-kappa Opioid Receptor (Ser369) in NIH/3T3 lysates using Phospho-kappa Opioid Receptor (Ser369) antibody.The lane on the right is blocked with the Phospho- peptide.
	Immunohistochemistry analysis of paraffin-embedded Human brain using Phospho-kappa Opioid Receptor (Ser369) antibody. High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.Sample with blocking peptide on the right.