中文 
别名:Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PP-1A, 3.1.3.16, PPP1CA, PPP1A应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. |
| Specification | |
|---|---|
| Aliases | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, PP-1A, 3.1.3.16, PPP1CA, PPP1A |
| Entrez GeneID | 5499 |
| Swissprot | P62136 |
| WB Predicted band size | 37.5kDa |
| Host/Isotype | Rabbit IgG |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This Phospho-PPP1CA (Thr320) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 291-324 amino acids from the human region of human PPP1CA. |
| Application | |
|---|---|
| WB | 1/1000 |
 |
Western blot analysis of lysates from Hela cell line, untreated or treated with paclitaxel, 100nM, 20hrs, using Phospho-PPP1CA (Thr320) Antibody (upper) or Beta-actin (lower). |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
暂无评论
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
发表回复