Rabbit Polyclonal Antibody to PIAS2

包装: 1G|100G|500G|1KG|100KG

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别名:DIP; MIZ; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4; PIASX-BETA; PIASX-ALPHA
应用:IHC
反应种属:Human, Mouse
规格：50μl/100μl

Description
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.

Description

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.

Specification
Aliases	DIP; MIZ; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4; PIASX-BETA; PIASX-ALPHA
Swissprot	O75928
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Synthetic peptide of human PIAS2
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/50-1/200
ELISA	1/1000-1/5000

	The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P04606(PIAS2 Antibody) at dilution 1/70. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human lymphoma tissue using P04606(PIAS2 Antibody) at dilution 1/70. (Original magnification: ×200)