Rabbit Polyclonal Antibody to PIAS4

包装: 1G|100G|500G|1KG|100KG

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别名:PIAS-gamma; PIASG; PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein PIASy
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005; 2005: 456. Amador Albor, J. Biol. Chem., Sep 2006; 281: 25850 – 25866. Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 – 16127. Yun Zhao, Stem Cells, Apr 2007; 10.1634.

Description

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005; 2005: 456. Amador Albor, J. Biol. Chem., Sep 2006; 281: 25850 – 25866. Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 – 16127. Yun Zhao, Stem Cells, Apr 2007; 10.1634.

Specification
Aliases	PIAS-gamma; PIASG; PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein PIASy
Entrez GeneID	51588;
Swissprot	Q8N2W9
WB Predicted band size	56kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from Internal of human PIAS4.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from Jurkat cells, using PIAS4 antibody P41842.
	Western blot analysis of extracts from JK cells (Lane 2), using PIAS4 antiobdy P41842. The lane on the left is treated with synthesized peptide.
	Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PIAS4 antibody P41842.