Rabbit Polyclonal Antibody to PIGA

包装: 1G|100G|500G|1KG|100KG

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别名:Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, GlcNAc-PI synthesis protein, Phosphatidylinositol-glycan biosynthesis class A protein, PIG-A, PIGA
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized. A related pseudogene is located on chromosome 12.

Description

This gene encodes a protein required for synthesis of
N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first
intermediate in the biosynthetic pathway of GPI anchor. The GPI
anchor is a glycolipid found on many blood cells and which serves
to anchor proteins to the cell surface. Paroxysmal nocturnal
hemoglobinuria, an acquired hematologic disorder, has been shown to
result from mutations in this gene. Alternate splice variants have
been characterized. A related pseudogene is located on chromosome
12.

Specification
Aliases	Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, GlcNAc-PI synthesis protein, Phosphatidylinositol-glycan biosynthesis class A protein, PIG-A, PIGA
Entrez GeneID	5277
Swissprot	P37287
WB Predicted band size	54.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This PIGA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 455-484 amino acids from the C-terminal region of human PIGA.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	PIGA Antibody (C-term) (Cat. #P31076) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the PIGA antibody detected the PIGA protein (arrow).
	PIGA Antibody (C-term) (Cat. #P31076)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PIGA Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.