Rabbit Polyclonal Antibody to PLCG1 (Ab-771)

包装: 1G|100G|500G|1KG|100KG

现货支持定制

QQ咨询
| 微信咨询

400-880-2824

满200元免运费
正品保障提供发票
现货闪电当时发货

别名:Phospholipase C gamma 1; PLC148; PHOSPHOLIPASE C-148;
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.Denis Tvorogov, J. Cell Sci., Feb 2005; 118: 601 – 610.Brenda J. Irvin, Mol. Cell. Biol., Dec 2000; 20: 9149 – 9161.Benoit Poulin, J. Biol. Chem., Feb 2000; 275: 6411.Ichiro Nakamura, J. Cell Biol., Jan 2001; 152: 361.

Description

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.Denis Tvorogov, J. Cell Sci., Feb 2005; 118: 601 – 610.Brenda J. Irvin, Mol. Cell. Biol., Dec 2000; 20: 9149 – 9161.Benoit Poulin, J. Biol. Chem., Feb 2000; 275: 6411.Ichiro Nakamura, J. Cell Biol., Jan 2001; 152: 361.

Specification
Aliases	Phospholipase C gamma 1; PLC148; PHOSPHOLIPASE C-148;
Entrez GeneID	5335;
Swissprot	P19174
WB Predicted band size	150kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized non-phosphopeptide derived from human PLCG1 around the phosphorylation site of tyrosine 771 (P-D-Y-G-A).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from COS7 cells treated with EGF (200ng/ml, 30min), using PLCG1 (Ab-771) antibody P41638.
	Western blot analysis of extracts from COS7 cells (Lane 2), and JK cells (Lane 3), using PLCG1 (Ab-771) antiobdy P41638. The lane on the left is treated with synthesized peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PLCG1 (Ab-771) antibody P41638.