Rabbit Polyclonal Antibody to PLD2 (Phospho-Tyr169)

包装: 1G|100G|500G|1KG|100KG

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别名:PLD 2; PLD1C; choline phosphatase 2;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.Steed P.M., FASEB J. 12:1309-1317(1998)Lopez I., J. Biol. Chem. 273:12846-12852(1998)Divecha N., EMBO J. 19:5440-5449(2000)

Description

Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.Steed P.M., FASEB J. 12:1309-1317(1998)Lopez I., J. Biol. Chem. 273:12846-12852(1998)Divecha N., EMBO J. 19:5440-5449(2000)

Specification
Aliases	PLD 2; PLD1C; choline phosphatase 2;
Entrez GeneID	5338;
Swissprot	O14939
WB Predicted band size	95kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of tyrosine 169(E-N-Y(p)-L-N) derived from Human PLD2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from Jurkat cells treated with TNF using PLD2 (Phospho-Tyr169) Antibody P40512.The lane on the right is treated with the antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using PLD2 (Phospho-Tyr169) antibody P40512 (left)or the same antibody preincubated with blocking peptide (right).