Rabbit Polyclonal Antibody to PON2 (N-term)

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别名:Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Description

This gene encodes a member of the paraoxonase gene family,
which includes three known members located adjacent to each other
on the long arm of chromosome 7. The encoded protein is
ubiquitously expressed in human tissues, membrane-bound, and may
act as a cellular antioxidant, protecting cells from oxidative
stress. Hydrolytic activity against acylhomoserine lactones,
important bacterial quorum-sensing mediators, suggests the encoded
protein may also play a role in defense responses to pathogenic
bacteria. Mutations in this gene may be associated with vascular
disease and a number of quantitative phenotypes related to
diabetes. Alternatively spliced transcript variants encoding
different isoforms have been described.

Specification
Aliases	Serum paraoxonase/arylesterase 2, PON 2, Aromatic esterase 2, A-esterase 2, Serum aryldialkylphosphatase 2, PON2
Entrez GeneID	5445
Swissprot	Q15165
WB Predicted band size	39.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This PON2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-107 amino acids from the N-terminal region of human PON2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	PON2 Antibody (N-term) (Cat. #P31191) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the PON2 antibody detected the PON2 protein (arrow).
	PON2 Antibody (N-term) (Cat. #P31191) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
	PON2 Antibody (N-term) (Cat. #P31191)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PON2 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.