Rabbit Polyclonal Antibody to POU5F1

包装: 1G|100G|500G|1KG|100KG

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别名:OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing’s sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

Description

This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development, especially during early embryogenesis, and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing’s sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation. Alternative splicing, as well as usage of alternative translation initiation codons, results in multiple isoforms, one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12.

Specification
Aliases	OCT3; OCT4; OTF3; OTF4; OTF-3; Oct-3; Oct-4
Entrez GeneID	5460;
Swissprot	Q01860
WB Predicted band size	39kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein corresponding to residues near the N terminal of human POU class 5 homeobox 1
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/500-1/2000
IHC	1/50-1/200

	Gel: 8%SDS-PAGE Lysate: 40ug K562 cell Primary antibody: 1/500 dilution Secondary antibody dilution: 1/8000 Exposure time: 30 seconds
	Immunohistochemical analysis of paraffin-embedded Human brain tissue using P42779 at dilution 1/30.