中文 
别名:MGC131930; PP4R2; protein phosphatase 4; regulatory subunit 2;应用:WB
反应种属:Human,Mouse
规格：50μl/100μl
| Description |
|---|
| Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on ‘Ser-140’ (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.Hastie C.J., Biochem. J. 347:845-855(2000).Zhang W., Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.Mural R.J., Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases |
| Specification | |
|---|---|
| Aliases | MGC131930; PP4R2; protein phosphatase 4; regulatory subunit 2; |
| Entrez GeneID | 151987; |
| Swissprot | Q9NY27 |
| WB Predicted band size | 50kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human PP4R2. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
 |
Western blot analysis of extracts from K562 cells and COS-7 cells, using PP4R2 antibody P42597. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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