Rabbit Polyclonal Antibody to Progesterone Receptor (Phospho-Ser294)

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别名:NR3C3; PGR; PRGR; Progesterone receptor;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.Chung HH, Sze SK, Tay AS, Lin VC (2014) J Biol Chem 289, 2180-94 Hagan CR, Knutson TP, Lange CA (2013) Nucleic Acids Res 41, 8926-42 Wang S, et al. (2013) J Biol Chem 288, 26265-74

Description

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.Chung HH, Sze SK, Tay AS, Lin VC (2014) J Biol Chem 289, 2180-94 Hagan CR, Knutson TP, Lange CA (2013) Nucleic Acids Res 41, 8926-42 Wang S, et al. (2013) J Biol Chem 288, 26265-74

Specification
Aliases	NR3C3; PGR; PRGR; Progesterone receptor;
Entrez GeneID	5241;
Swissprot	P06401
WB Predicted band size	99kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Peptide sequence around phosphorylation site of serine 294 (G-R-S(p)-P-L) derived from Human Progesterone Receptor.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000

Western blot analysis of extracts from 293 cells treated with Etoposide using Phospho-Progesterone Receptor (Ser294) antibody P40624.The lane on the right is treated with the antigen-specific peptide.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

Rabbit Polyclonal Antibody to Progesterone Receptor (Phospho-Ser294)

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