Rabbit Polyclonal Antibody to PSMB11

包装: 1G|100G|500G|1KG|100KG

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别名:Proteasome subunit beta type-11, Proteasome subunit beta-5t, PSMB11
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Proteasomes generate peptides that are presented by major histocompatibility complex (MHC) I molecules to other cells of the immune system. Proteolysis is conducted by 20S proteasomes, complexes of 28 subunits arranged as a cylinder in 4 heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7, and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM 600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM 600306). Three additional subunits, beta-1i (PSMB9; MIM 177045), beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are induced by gamma-interferon (IFNG; MIM 147570) and are preferentially incorporated into proteasomes to make immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit expressed exclusively in cortical thymic epithelial cells (Murata et al., 2007 [PubMed 17540904]).

Description

Proteasomes generate peptides that are presented by major
histocompatibility complex (MHC) I molecules to other cells of the
immune system. Proteolysis is conducted by 20S proteasomes,
complexes of 28 subunits arranged as a cylinder in 4
heteroheptameric rings: alpha-1 to -7, beta-1 to -7, beta-1 to -7,
and alpha-1 to -7. The catalytic subunits are beta-1 (PSMB6; MIM
600307), beta-2 (PSMB7; MIM 604030), and beta-5 (PSMB5; MIM
600306). Three additional subunits, beta-1i (PSMB9; MIM 177045),
beta-2i (PSMB10; MIM 176847), and beta-5i (PSMB8; MIM 177046), are
induced by gamma-interferon (IFNG; MIM 147570) and are
preferentially incorporated into proteasomes to make
immunoproteasomes. PSMB11, or beta-5t, is a catalytic subunit
expressed exclusively in cortical thymic epithelial cells (Murata
et al., 2007 [PubMed 17540904]).

Specification
Aliases	Proteasome subunit beta type-11, Proteasome subunit beta-5t, PSMB11
Entrez GeneID	122706
Swissprot	A5LHX3
WB Predicted band size	32.5kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This PSMB11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human PSMB11.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.