Rabbit Polyclonal Antibody to PTCH1

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别名:PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Description

This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.

Specification
Aliases	PTCH1; PTCH; Protein patched homolog 1; PTC; PTC1
Entrez GeneID	5727
Swissprot	Q13635
WB Predicted band size	Calculated MW: 161 kDa; Observed MW: 161 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	The antiserum was produced against synthesized peptide derived from human Patched. AA range:1-50
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Application
WB	1/500-1/1000
IHC	1/50-1/100
ELISA	1/10000

	Immunohistochemical analysis of paraffin-embedded Human tonsils using PTCH1 antibody.High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.
	Immunohistochemistry analysis of paraffin-embedded Human testis using PTCH1 antibody. High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.
	Immunohistochemistry analysis of paraffin-embedded Human Right kidney using PTCH1 antibody.High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.
	Immunohistochemistry analysis of paraffin-embedded Human Right kidney using PTCH1 antibody.High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.
	Immunohistochemistry analysis of paraffin-embedded Human testis using PTCH1 antibody.High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.
	Immunohistochemistry analysis of paraffin-embedded Human Right kidney using PTCH1 antibody. High-pressure and temperature Tris-EDTA pH 8.0 was used for antigen retrieval.