Rabbit Polyclonal Antibody to PTPN2

包装: 1G|100G|500G|1KG|100KG

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别名:Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase, TCPTP, PTPN2, PTPT
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq].

Description

The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. Members of the PTP
family share a highly conserved catalytic motif, which is essential
for the catalytic activity. PTPs are known to be signaling
molecules that regulate a variety of cellular processes including
cell growth, differentiation, mitotic cycle, and oncogenic
transformation. Epidermal growth factor receptor and the adaptor
protein Shc were reported to be substrates of this PTP, which
suggested the roles in growth factor mediated cell signaling. Three
alternatively spliced variants of this gene, which encode isoforms
differing at their extreme C-termini, have been described. The
different C-termini are thought to determine the substrate
specificity, as well as the cellular localization of the isoforms.
Two highly related but distinctly processed pseudogenes that
localize to distinct chromosomes have been reported. [provided by
RefSeq].

Specification
Aliases	Tyrosine-protein phosphatase non-receptor type 2, T-cell protein-tyrosine phosphatase, TCPTP, PTPN2, PTPT
Entrez GeneID	5771
Swissprot	P17706
WB Predicted band size	48.5kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This PTPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of human PTPN2.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	PTPN2 Antibody (C-term) (Cat. #P31264) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the PTPN2 antibody detected the PTPN2 protein (arrow).
	PTPN2 Antibody (C-term) (Cat. #P31264)immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PTPN2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.