Rabbit Polyclonal Antibody to PYK2 (Phospho-Tyr579)

包装: 1G|100G|500G|1KG|100KG

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别名:CADTK; FADK 2; FAK2; PTK2B; RAFTK
应用:WB,IHC
反应种属:Human,Mouse
规格：50μl/100μl

Description
Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA ‘Tyr-125’ phosphorylation.Lev S., Nature 376:737-745(1995)Herzog H., Genomics 32:484-486(1996)Sasaki H., J. Biol. Chem. 270:21206-21219(1995)

Description

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA ‘Tyr-125’ phosphorylation.Lev S., Nature 376:737-745(1995)Herzog H., Genomics 32:484-486(1996)Sasaki H., J. Biol. Chem. 270:21206-21219(1995)

Specification
Aliases	CADTK; FADK 2; FAK2; PTK2B; RAFTK
Entrez GeneID	2185;
Swissprot	Q14289
WB Predicted band size	116kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around phosphorylation site of tyrosine 579(E-D-Y(p)-Y-K) derived from Human PYK2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100

	Western blot analysis of extracts from 3T3 cells (Lane 2) and HepG2 cells (Lane 3), using PYK2 (Phospho-Tyr579) Antibody P40476. The lane on the left is treated with antigen-specific peptide.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using PYK2 (Phospho-Tyr579) antibody P40476 (left)or the same antibody preincubated with blocking peptide (right).