Rabbit Polyclonal Antibody to RAB31

包装: 1G|100G|500G|1KG|100KG

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别名:Ras-related protein Rab-31; Ras-related protein Rab-22B;
应用:WB
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.Chen D., Gene 174:129-134(1996) [PubMed: 8863739].Bao X.,Eur. J. Biochem. 269:259-271(2002) [PubMed: 11784320].Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039].

Description

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.Chen D., Gene 174:129-134(1996) [PubMed: 8863739].Bao X.,Eur. J. Biochem. 269:259-271(2002) [PubMed: 11784320].Ota T., Nat. Genet. 36:40-45(2004) [PubMed: 14702039].

Specification
Aliases	Ras-related protein Rab-31; Ras-related protein Rab-22B;
Entrez GeneID	11031;
Swissprot	Q13636
WB Predicted band size	21kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from internal of human RAB31.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.