Rabbit Polyclonal Antibody to RAD18

包装: 1G|100G|500G|1KG|100KG

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别名:E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; postreplication repair protein hRAD18p; Postreplication repair protein RAD18
应用:WB
反应种属:Human
规格：50μl/100μl

Description
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on ‘Lys-164’. Has ssDNA binding activity.Tateishi S., Proc. Natl. Acad. Sci. U.S.A. 97:7927-7932(2000).Xin H., Nucleic Acids Res. 28:2847-2854(2000).Muzny D.M., Nature 440:1194-1198(2006).

Description

E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on ‘Lys-164’. Has ssDNA binding activity.Tateishi S., Proc. Natl. Acad. Sci. U.S.A. 97:7927-7932(2000).Xin H., Nucleic Acids Res. 28:2847-2854(2000).Muzny D.M., Nature 440:1194-1198(2006).

Specification
Aliases	E3 ubiquitin-protein ligase RAD18; hHR18; hRAD18; postreplication repair protein hRAD18p; Postreplication repair protein RAD18
Entrez GeneID	56852;
Swissprot	Q9NS91
WB Predicted band size	56kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human RAD18.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.