Rabbit Polyclonal Antibody to RBBP8

包装: 1G|100G|500G|1KG|100KG

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别名:RIM; COM1; CTIP; JWDS; SAE2; SCKL2
应用:WB,IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1.

Description

The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1.

Specification
Aliases	RIM; COM1; CTIP; JWDS; SAE2; SCKL2
Swissprot	Q99708
WB Predicted band size	102 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human RBBP8
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/200-1/1000
IHC	1/100-1/300
ELISA	1/5000-1/10000

	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hepg2, Hela and 231 cell, Primary antibody: P08186(RBBP8 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 seconds
	The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P08186(RBBP8 Antibody) at dilution 1/45. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08186(RBBP8 Antibody) at dilution 1/45. (Original magnification: ×200)