Rabbit Polyclonal Antibody to RBL2

包装: 1G|100G|500G|1KG|100KG

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别名:Rb2; P130
应用:WB,IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ‘Lys-20’ trimethylation.

Description

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 ‘Lys-20’ trimethylation.

Specification
Aliases	Rb2; P130
Swissprot	Q08999
WB Predicted band size	128 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide of human RBL2
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/200-1/1000
IHC	1/30-1/150
ELISA	1/5000-1/10000

	Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Lncap cell, Primary antibody: P04620(RBL2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes
	The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P04620(RBL2 Antibody) at dilution 1/40. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human brain tissue using P04620(RBL2 Antibody) at dilution 1/40. (Original magnification: ×200)