Rabbit Polyclonal Antibody to RBP3

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别名:Retinol-binding protein 3, Interphotoreceptor retinoid-binding protein, IRBP, Interstitial retinol-binding protein, RBP3
应用:WB
反应种属:Human, Mouse
规格：50μl/100μl

Description
Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.

Description

Interphotoreceptor retinol-binding protein is a large
glycoprotein known to bind retinoids and found primarily in the
interphotoreceptor matrix of the retina between the retinal pigment
epithelium and the photoreceptor cells. It is thought to transport
retinoids between the retinal pigment epithelium and the
photoreceptors, a critical role in the visual process.The human
IRBP gene is approximately 9.5 kbp in length and consists of four
exons separated by three introns. The introns are 1.6-1.9 kbp long.
The gene is transcribed by photoreceptor and retinoblastoma cells
into an approximately 4.3-kilobase mRNA that is translated and
processed into a glycosylated protein of 135,000 Da. The amino acid
sequence of human IRBP can be divided into four contiguous homology
domains with 33-38% identity, suggesting a series of gene
duplication events. In the gene, the boundaries of these domains
are not defined by exon-intron junctions, as might have been
expected. The first three homology domains and part of the fourth
are all encoded by the first large exon, which is 3,180 base pairs
long. The remainder of the fourth domain is encoded in the last
three exons, which are 191, 143, and approximately 740 base pairs
long, respectively.

Specification
Aliases	Retinol-binding protein 3, Interphotoreceptor retinoid-binding protein, IRBP, Interstitial retinol-binding protein, RBP3
Entrez GeneID	5949
Swissprot	P10745
WB Predicted band size	135.4kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	This RBP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 784-811 amino acids from the Central region of human RBP3.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.