Rabbit Polyclonal Antibody to RB(Phospho-Ser811)

包装: 1G|100G|500G|1KG|100KG

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别名:OSRC;PPP1R130;RB;p105-Rb;pRb;pp110;RB1;Rb
应用:WB
反应种属:Human
规格：50μl/100μl

Description
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Description

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Specification
Aliases	OSRC;PPP1R130;RB;p105-Rb;pRb;pp110;RB1;Rb
Entrez GeneID	5925
Swissprot	P06400
WB Predicted band size	106kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	A synthetic phosphorylated peptide around S811 of human RB (NP_000312.2).
Formulation	PBS with 0.02% sodium azide,50% glycerol,pH7.3.