Rabbit Polyclonal Antibody to RCC1

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别名:CHC1; Cell cycle regulatory protein; Regulator of chromosome condensation;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.M Dasso, Mol. Cell. Biol., Aug 1992; 12: 3337 – 3345. Hoi Yeung Li, J. Cell Biol., Mar 2003; 160: 635. Michael E. Nemergut, Science, May 2001; 292: 1540. Ian Cushman, Mol. Biol. Cell, Jan 2004; 15: 245.

Description

Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.M Dasso, Mol. Cell. Biol., Aug 1992; 12: 3337 – 3345. Hoi Yeung Li, J. Cell Biol., Mar 2003; 160: 635. Michael E. Nemergut, Science, May 2001; 292: 1540. Ian Cushman, Mol. Biol. Cell, Jan 2004; 15: 245.

Specification
Aliases	CHC1; Cell cycle regulatory protein; Regulator of chromosome condensation;
Entrez GeneID	1104;;
Swissprot	P18754
WB Predicted band size	58kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from human RCC1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from LOVO cells, using RCC1 antibody P41830.
	Western blot analysis of extracts from HepG2 cells (Lane 2), cells (Lane 3) and cells (Lane 4), using RCC1 antiobdy P41830. The lane on the left is treated with systhesized peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using RCC1 antibody P41830.