Rabbit Polyclonal Antibody to Retinoic Acid Receptor β

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别名:RAR-beta;
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5′-AGGTCA-3′ sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.Reuben Lotan, N. Engl. J. Med., May 1995; 332: 1405 – 1411. Andrew Yen, Mol. Pharmacol., Dec 2004; 66: 1727 – 1737. K Swisshelm, Cell Growth Differ., Feb 1994; 5: 133. F Aoudjit, Cell Growth Differ., May 1995; 6: 515.

Description

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5′-AGGTCA-3′ sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.Reuben Lotan, N. Engl. J. Med., May 1995; 332: 1405 – 1411. Andrew Yen, Mol. Pharmacol., Dec 2004; 66: 1727 – 1737. K Swisshelm, Cell Growth Differ., Feb 1994; 5: 133. F Aoudjit, Cell Growth Differ., May 1995; 6: 515.

Specification
Aliases	RAR-beta;
Entrez GeneID	5915;
Swissprot	P10826
WB Predicted band size	50kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from human Retinoic Acid Receptor β.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HepG2 cells, using Retinoic Acid Receptor β antibody P41831.
	Western blot analysis of extracts from K562 cells (Lane 2), using Retinoic Acid Receptor β antiobdy P41831. The lane on the left is treated with synthesized peptide.
	Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Retinoic Acid Receptor β antibody P41831.