Rabbit Polyclonal Antibody to RHOC

包装: 1G|100G|500G|1KG|100KG

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别名:Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC
应用:WB
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Description

This gene encodes a member of the Rho family of small
GTPases, which cycle between inactive GDP-bound and active
GTP-bound states and function as molecular switches in signal
transduction cascades. Rho proteins promote reorganization of the
actin cytoskeleton and regulate cell shape, attachment, and
motility. The protein encoded by this gene is prenylated at its
C-terminus, and localizes to the cytoplasm and plasma membrane. It
is thought to be important in cell locomotion. Overexpression of
this gene is associated with tumor cell proliferation and
metastasis. Multiple alternatively spliced variants, encoding the
same protein, have been identified.

Specification
Aliases	Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC
Entrez GeneID	389
Swissprot	P08134
WB Predicted band size	22.0kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	This RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human RHOC.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/2000

All lanes : Anti-RHOC Antibody (C-term) at 1:2000 dilution
Lane 1: HL-60 whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: NIH/3T3 whole cell lysate

Lysates/proteins at 20 µg per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.

Predicted band size : 22 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。

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