Rabbit Polyclonal Antibody to RIOX1

包装: 1G|100G|500G|1KG|100KG

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别名:ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169
应用:IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ‘Lys-4’ (H3K4me) and ‘Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ‘Lys-4’ (H3K4me3) and monomethylated H3 ‘Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ‘Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ‘His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

Description

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates ‘Lys-4’ (H3K4me) and ‘Lys-36’ (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ‘Lys-4’ (H3K4me3) and monomethylated H3 ‘Lys-4’ (H3K4me1) residues, while it has weaker activity for dimethylated H3 ‘Lys-36’ (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on ‘His-216’. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

Specification
Aliases	ROX; NO66; JMJD9; MAPJD; URLC2; hsNO66; C14orf169
Swissprot	Q9H6W3
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide of human RIOX1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
IHC	1/30-1/150
ELISA	1/5000-1/10000

	The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12979(RIOX1 Antibody) at dilution 1/45. (Original magnification: ×200)
	The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12979(RIOX1 Antibody) at dilution 1/45. (Original magnification: ×200)