Rabbit Polyclonal Antibody to RNF19A

包装: 1G|100G|500G|1KG|100KG

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别名:E3 ubiquitin-protein ligase RNF19A, 632-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson’s disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.

Description

The protein encoded this gene contains two RING-finger
motifs and an IBR (in between RING fingers) motif. This protein is
an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a
characteristic neuronal inclusion in Parkinson’s disease (PD)
brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8,
but not other ubiquitin-conjugating enzymes. This protein is found
to bind and ubiquitylate synphilin 1 (SNCAIP), which is a
interacting protein of alpha synuclein in neurons, and a major
component of LB. Alternatively spliced transcript variants encoding
the same protein have been reported.

Specification
Aliases	E3 ubiquitin-protein ligase RNF19A, 632-, Double ring-finger protein, Dorfin, RING finger protein 19A, p38, RNF19A, RNF19
Entrez GeneID	25897
Swissprot	Q9NV58
WB Predicted band size	90.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This RNF19A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	RNF19A Antibody (Center) (Cat. #P31420) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the RNF19A antibody detected the RNF19A protein (arrow).
	RNF19A Antibody (Center) (P31420)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of RNF19A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.