Rabbit Polyclonal Antibody to RNH1

包装: 1G|100G|500G|1KG|100KG

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别名:Ribonuclease inhibitor, Placental ribonuclease inhibitor, Placental RNase inhibitor, Ribonuclease/angiogenin inhibitor 1, RAI, RNH1, PRI, RNH
应用:WB,ICC
反应种属:Human
规格：50μl/100μl

Description
Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.

Description

Placental ribonuclease inhibitor (PRI) is a member of a
family of proteinaceous cytoplasmic RNase inhibitors that occur in
many tissues and bind to both intracellular and extracellular
RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In
addition to control of intracellular RNases, the inhibitor may have
a role in the regulation of angiogenin (MIM 105850). Ribonuclease
inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a
latent form. Since neutral and alkaline ribonucleases probably play
a critical role in the turnover of RNA in eukaryotic cells, RNH may
be essential for control of mRNA turnover; the interaction of
eukaryotic cells with ribonuclease may be reversible in
vivo.

Specification
Aliases	Ribonuclease inhibitor, Placental ribonuclease inhibitor, Placental RNase inhibitor, Ribonuclease/angiogenin inhibitor 1, RAI, RNH1, PRI, RNH
Entrez GeneID	6050
Swissprot	P13489
WB Predicted band size	50.0kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This RNH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 425-454 amino acids from the C-terminal region of human RNH1.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000-1/2000
ICC	1/10-1/50

	Western blot analysis of lysate from HT29 cell line,using RNH1 Antibody (C-term)(Cat. #P32575).P32575 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody.Lysate at 35ug per lane.
	Confocal immunofluorescent analysis of RNH1 Antibody (C-term) (Cat#P32575) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).