Rabbit Polyclonal Antibody to RPC2

包装: 1G|100G|500G|1KG|100KG

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别名:DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide; EC 2.7.7.6; polymerase (RNA) III (DNA directed) polypeptide B; RNA polymerase III subunit 2; RNA polymerase III subunit RPC2
应用:WB
反应种属:Human,Mouse
规格：50μl/100μl

Description
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft By similarity. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.Hu P., Mol. Cell. Biol. 22:8044-8055(2002).The MGC Project Team; Genome Res. 14:2121-2127(2004).Ota T., Nat. Genet. 36:40-45(2004).

Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft By similarity. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.Hu P., Mol. Cell. Biol. 22:8044-8055(2002).The MGC Project Team; Genome Res. 14:2121-2127(2004).Ota T., Nat. Genet. 36:40-45(2004).

Specification
Aliases	DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide; EC 2.7.7.6; polymerase (RNA) III (DNA directed) polypeptide B; RNA polymerase III subunit 2; RNA polymerase III subunit RPC2
Entrez GeneID	55703;
Swissprot	Q9NW08
WB Predicted band size	128kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthesized peptide derived from internal of human RPC2.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.