Rabbit Polyclonal Antibody to RPS19

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别名:40S ribosomal protein S19, RPS19
应用:WB,FCM
反应种属:Human
规格：50μl/100μl

Description
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Description

Ribosomes, the organelles that catalyze protein synthesis,
consist of a small 40S subunit and a large 60S subunit. Together
these subunits are composed of 4 RNA species and approximately 80
structurally distinct proteins. This gene encodes a ribosomal
protein that is a component of the 40S subunit. The protein belongs
to the S19E family of ribosomal proteins. It is located in the
cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia
(DBA), a constitutional erythroblastopenia characterized by absent
or decreased erythroid precursors, in a subset of patients. This
suggests a possible extra-ribosomal function for this gene in
erythropoietic differentiation and proliferation, in addition to
its ribosomal function. Higher expression levels of this gene in
some primary colon carcinomas compared to matched normal colon
tissues has been observed. As is typical for genes encoding
ribosomal proteins, there are multiple processed pseudogenes of
this gene dispersed through the genome.

Specification
Aliases	40S ribosomal protein S19, RPS19
Entrez GeneID	6223
Swissprot	P39019
WB Predicted band size	16.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This RPS19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the Central region of human RPS19.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
FCM	1/10-1/50

	RPS19 Antibody (Center) (Cat. #P31032) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the RPS19 antibody detected the RPS19 protein (arrow).
	RPS19 Antibody (Center) (Cat. #P31032) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.