Rabbit Polyclonal Antibody to RRAGA

包装: 1G|100G|500G|1KG|100KG

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别名:FIP1; RAGA; FIP-1
应用:WB,IHC
反应种属:Human, Mouse, Rat
规格：50μl/100μl

Description
Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGAgene. Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.

Description

Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGAgene. Guanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death.

Specification
Aliases	FIP1; RAGA; FIP-1
Swissprot	Q7L523
WB Predicted band size	37 kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse, Rat
Immunogen	Fusion protein of human RRAGA
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Application
WB	1/500-1/2000
IHC	1/25-1/100
ELISA	1/2000-1/5000

	Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hepg2 cells, hela cells, Primary antibody: P08725(RRAGA Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds
	The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P08725(RRAGA Antibody) at dilution 1/25. (Original magnification: ×200)