Rabbit Polyclonal Antibody to RSPO4

包装: 1G|100G|500G|1KG|100KG

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别名:R-spondin-4, Roof plate-specific spondin-4, hRspo4, RSPO4, C20orf182
应用:WB,IHC,FCM
反应种属:Human
规格：50μl/100μl

Description
RSPO4 is a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.

Description

RSPO4 is a member of the R-spondin family of
proteins that share a common domain organization consisting of a
signal peptide, cysteine-rich/furin-like domain, thrombospondin
domain and a C-terminal basic region. The encoded protein may be
involved in activation of Wnt/beta-catenin signaling pathways.
Mutations in this gene are associated with anonychia congenital.
Alternate splicing results in multiple transcript variants.

Specification
Aliases	R-spondin-4, Roof plate-specific spondin-4, hRspo4, RSPO4, C20orf182
Entrez GeneID	343637
Swissprot	Q2I0M5
WB Predicted band size	26.2kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This RSPO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the C-terminal region of human RSPO4.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
FCM	1/10-1/50

	RSPO4 Antibody (C-term) (Cat. #P30710) western blot analysis in Jurkat cell line lysates (15ug/lane).This demonstrates the RSPO4 antibody detected the RSPO4 protein (arrow).
	RSPO4 Antibody (C-term) (Cat. #P30710) flow cytometric analysis of Jurkat cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
	RSPO4 Antibody (C-term) (Cat. #P30710) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the RSPO4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.