Rabbit Polyclonal Antibody to S adenosylhomocysteine hydrolase (ACHY)

包装: 1G|100G|500G|1KG|100KG

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别名:Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
S-adenosylhomocysteine hydrolase (AHCY) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family.

Description

S-adenosylhomocysteine hydrolase (AHCY) catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family.

Specification
Aliases	Adenosylhomocysteinase, AdoHcyase, S-adenosyl-L-homocysteine hydrolase, AHCY, SAHH
Entrez GeneID	191
Swissprot	P23526
WB Predicted band size	47.7kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This S adenosylhomocysteine hydrolase (ACHY) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-432 amino acids from the C-terminal region of human S adenosylhomocysteine hydrolase (ACHY).
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Application
WB	1/1000
IHC	1/100-1/500

	Western blot analysis of anti-AHCY Antibody (C-term)(Cat.#P30268) in HepG2 cell line lysates (35ug/lane). AHCY(arrow) was detected using the purified Pab.
	Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with AHCY antibody (C-term) (Cat.#P30268), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.