Rabbit Polyclonal Antibody to S10A1

包装: 1G|100G|500G|1KG|100KG

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别名:S100-ALPHA ; S100 CALCIUM-BINDING PROTEIN A1;
应用:WB,IHC,ICC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.Patrick Most, J. Biol. Chem., Nov 2003; 278: 48404 – 48412. Miki Okada, J. Biol. Chem., Feb 2004; 279: 4221 – 4233. Melanie Boerries, Mol. Cell. Biol., Jun 2007; 27: 4365 – 4373. Patrick Most, J. Clin. Invest., Dec 2004; 114: 1550 – 1563.

Description

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.Patrick Most, J. Biol. Chem., Nov 2003; 278: 48404 – 48412. Miki Okada, J. Biol. Chem., Feb 2004; 279: 4221 – 4233. Melanie Boerries, Mol. Cell. Biol., Jun 2007; 27: 4365 – 4373. Patrick Most, J. Clin. Invest., Dec 2004; 114: 1550 – 1563.

Specification
Aliases	S100-ALPHA ; S100 CALCIUM-BINDING PROTEIN A1;
Entrez GeneID	6271;
Swissprot	P23297
WB Predicted band size	10kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human S100 A1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from A549 cells, using S100 A1 antibody P41834.
	Western blot analysis of extracts from 293 cells (Lane 2), using S100 A1 antiobdy P41834. The lane on the left is treated with synthesized peptide.
	Immunofluorescence analysis of A549 cells, using S100 A1 antibody P41834.
	Immunohistochemical analysis of paraffin-embedded human brain tissue using S100 A1 antibody P41834.