Rabbit Polyclonal Antibody to SEC62 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Translocation protein SEC62, Translocation protein 1, TP-1, hTP-1, SEC62, TLOC1
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Description

The Sec61 complex is the central component of the protein
translocation apparatus of the endoplasmic reticulum (ER) membrane.
The protein encoded by this gene and SEC63 protein are found to be
associated with ribosome-free SEC61 complex. It is speculated that
Sec61-Sec62-Sec63 may perform post-translational protein
translocation into the ER. The Sec61-Sec62-Sec63 complex might also
perform the backward transport of ER proteins that are subject to
the ubiquitin-proteasome-dependent degradation pathway. The encoded
protein is an integral membrane protein located in the rough ER.

Specification
Aliases	Translocation protein SEC62, Translocation protein 1, TP-1, hTP-1, SEC62, TLOC1
Entrez GeneID	7095
Swissprot	Q99442
WB Predicted band size	45.9kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This SEC62 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SEC62.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	SEC62 Antibody (N-term) (Cat. #P31176) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the SEC62 antibody detected the SEC62 protein (arrow).
	SEC62 Antibody (N-term) (Cat. #P31176)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEC62 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.