Rabbit Polyclonal Antibody to SEPT5 (N-term)

包装: 1G|100G|500G|1KG|100KG

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别名:Septin-5, Cell division control-related protein 1, CDCrel-1, Peanut-like protein 1, SEPT5, PNUTL1
应用:WB,IHC
反应种属:Human
规格：50μl/100μl

Description
This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq].

Description

This gene is a member of the septin gene family of
nucleotide binding proteins, originally described in yeast as cell
division cycle regulatory proteins. Septins are highly conserved in
yeast, Drosophila, and mouse and appear to regulate cytoskeletal
organization. Disruption of septin function disturbs cytokinesis
and results in large multinucleate or polyploid cells. This gene is
mapped to 22q11, the region frequently deleted in DiGeorge and
velocardiofacial syndromes. A translocation involving the MLL gene
and this gene has also been reported in patients with acute myeloid
leukemia. Alternative splicing results in multiple transcript
variants. The presence of a non-consensus polyA signal (AACAAT) in
this gene also results in read-through transcription into the
downstream neighboring gene (GP1BB; platelet glycoprotein Ib),
whereby larger, non-coding transcripts are produced. [provided by
RefSeq].

Specification
Aliases	Septin-5, Cell division control-related protein 1, CDCrel-1, Peanut-like protein 1, SEPT5, PNUTL1
Entrez GeneID	5413
Swissprot	Q99719
WB Predicted band size	42.8kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	This SEPT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human SEPT5.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500

	Western blot analysis of lysate from human brain tissue lysate, using SEPT5 Antibody (N-term)(Cat. #P31528). P31528 was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.
	SEPT5 Antibody (N-term) (P31528)immunohistochemistry analysis in formalin fixed and paraffin embedded human cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SEPT5 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.