Rabbit Polyclonal Antibody to SERPINE1

包装: 1G|100G|500G|1KG|100KG

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别名:PAI; PAI1; PAI-1; PLANH1
应用:IHC
反应种属:Human
规格：50μl/100μl

Description
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Description

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Specification
Aliases	PAI; PAI1; PAI-1; PLANH1
Entrez GeneID	5054;
Swissprot	P05121
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Fusion protein corresponding to a region derived from internal residues of human serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
IHC	1/25-1/100

	Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using P42780 at dilution 1/20.
	Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using P42780 at dilution 1/20.