中文 
别名:KMT7; SET7; SET9; SET7/9应用:WB,IHC
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| The methylation of histones plays a pivotal role in the regulation of chromatin structure and gene expression. Histone methylation can occur on Arg or Lys residues, with an exquisite site selectivity for Lys methylation at specific positions in the N-termini of histones H3 and H4. SET7/9, a histone methyltransferase (HMTase), which transfers methyl groups to Lys4 of histone H3, forms a complex with S-adenosyl-L-methionine. This complex contains an active site consisting of a binding pocket where an AdoMet molecule in an unusual conformation binds, a narrow substrate-specific channel that only unmethylated lysine residues can access and a catalytic tyrosine residue. |
| Specification | |
|---|---|
| Aliases | KMT7; SET7; SET9; SET7/9 |
| Entrez GeneID | 80854; |
| Swissprot | Q8WTS6 |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to residues near the C terminal of human SET domain containing (lysine methyltransferase) 7 |
| Formulation | Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/1000 |
| IHC | 1/50-1/200 |
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Immunohistochemical analysis of paraffin-embedded Human tonsil cancer tissue using P42825 at dilution 1/20. |
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Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using P42825 at dilution 1/20. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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