Rabbit Polyclonal Antibody to SGOL1

包装: 1G|100G|500G|1KG|100KG

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别名:Shugoshin-like 1; hSgo1; Serologically defined breast cancer antigen NY-BR-85; SGO1;
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.McGuinness B.E., PLoS Biol. 3:433-449(2005).Kitajima T.S., Curr. Biol. 15:353-359(2005).Tang Z., Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004).

Description

Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.McGuinness B.E., PLoS Biol. 3:433-449(2005).Kitajima T.S., Curr. Biol. 15:353-359(2005).Tang Z., Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004).

Specification
Aliases	Shugoshin-like 1; hSgo1; Serologically defined breast cancer antigen NY-BR-85; SGO1;
Entrez GeneID	151648;
Swissprot	Q5FBB7
WB Predicted band size	64kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human SGOL1.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.