Rabbit Polyclonal Antibody to SIRT5

包装: 1G|100G|500G|1KG|100KG

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别名:Sirtuin 5, SIR2L5
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Description

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants.

Specification
Aliases	Sirtuin 5, SIR2L5
Entrez GeneID	23408;
Swissprot	Q9NXA8
WB Predicted band size	22kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide corresponding to a region derived from 229-242 amino acids of Human sirtuin 5
Formulation	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

Application
WB	1/500-1/2000
IHC	1/25-1/100
ELISA	1:1000-1:5000

	Gel: 10%SDS-PAGE Lysate: 40ug Mouse heart tissue lysate Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG – H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds
	The image on the left is immunohistochemistry of paraffin-embedded human breast cancer tissue using 31267 (SIRT5 Antibody) at dilution 1/25, on the right is treated with the synthetic peptide.