中文 
别名:Homeobox protein SIX1, Sine oculis homeobox homolog 1, SIX1应用:WB
反应种属:Human, Mouse
规格：50μl/100μl
| Description |
|---|
| Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development. Plays an important role in the development of several organs, including kidney, muscle and inner ear. Depending on context, functions as transcriptional repressor or activator. Lacks an activation domain, and requires interaction with EYA family members for transcription activation. Mediates nuclear translocation of EYA1 and EYA2. Binds the 5′-TCA[AG][AG]TTNC-3′ motif present in the MEF3 element in the MYOG promoter. Regulates the expression of numerous genes, including MYC, CCND1 and EZR. Acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex. During myogenesis, seems to act together with EYA2 and DACH2 (By similarity). Regulates the expression of CCNA1. |
| Specification | |
|---|---|
| Aliases | Homeobox protein SIX1, Sine oculis homeobox homolog 1, SIX1 |
| Entrez GeneID | 6495 |
| Swissprot | Q15475 |
| WB Predicted band size | 32.2kDa |
| Host/Isotype | Rabbit IgG |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This SIX1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 69-102 amino acids from the Central region of human SIX1. |
| Application | |
|---|---|
| WB | 1/2000 |
 |
All lanes : Anti-SIX1 Antibody (Center) at 1:2000 dilution Lane 1: Jurkat whole cell lysate Lane 2: NIH/3T3 whole cell lysate Lane 3: U-2OS whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Predicted band size : 32 kDa Blocking/Dilution buffer: 5% NFDM/TBST. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
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