Rabbit Polyclonal Antibody to SLC27A5

包装: 1G|100G|500G|1KG|100KG

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别名:EC 6.2.1.7; FACVL3; FATP5; MGC143799; S27A5
应用:WB,IHC,ICC
反应种属:Human
规格：50μl/100μl

Description
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.Steinberg S.J., Mol. Genet. Metab. 68:32-42(1999).Steinberg S.J., J. Biol. Chem. 275:15605-15608(2000).Mihalik S.J., J. Biol. Chem. 277:24771-24779(2002).

Description

Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.Steinberg S.J., Mol. Genet. Metab. 68:32-42(1999).Steinberg S.J., J. Biol. Chem. 275:15605-15608(2000).Mihalik S.J., J. Biol. Chem. 277:24771-24779(2002).

Specification
Aliases	EC 6.2.1.7; FACVL3; FATP5; MGC143799; S27A5
Entrez GeneID	10998;
Swissprot	Q9Y2P5
WB Predicted band size	75kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized peptide derived from internal of human SLC27A5.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100
ICC	1/100-1/500

	Western blot analysis of extracts from HepG2 cells, using SLC27A5 antibody P42319.
	Immunofluorescence analysis of A549 cells, using SLC27A5 antibody P42319.
	Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using SLC27A5 antibody P42319.