Rabbit Polyclonal Antibody to SMAD3

包装: 1G|100G|500G|1KG|100KG

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别名:Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3
应用:WB,IHC,ICC
反应种属:Rat, Human
规格：50μl/100μl

Description
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic’ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

Description

The protein encoded by this gene belongs to the SMAD, a
family of proteins similar to the gene products of the Drosophila
gene ‘mothers against decapentaplegic’ (Mad) and the C. elegans
gene Sma. SMAD proteins are signal transducers and transcriptional
modulators that mediate multiple signaling pathways. This protein
functions as a transcriptional modulator activated by transforming
growth factor-beta and is thought to play a role in the regulation
of carcinogenesis.

Specification
Aliases	Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, hMAD-3, JV15-2, SMAD family member 3, SMAD 3, Smad3, hSMAD3, SMAD3, MADH3
Entrez GeneID	4088
Swissprot	P84022
WB Predicted band size	48.1kDa
Host/Isotype	Rabbit IgG
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Rat, Human
Immunogen	This SMAD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-156 amino acids from the Central region of human SMAD3.
Formulation	Purified polyclonal antibody supplied in PBS with 0.05% sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Application
WB	1/1000
IHC	1/100-1/500
ICC	1/10-1/50

	SMAD3 Antibody (Center) (Cat. #P31307) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the SMAD3 antibody detected the SMAD3 protein (arrow).
	Confocal immunofluorescent analysis of SMAD3 Antibody (Center)(Cat#P31307) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red).DAPI was used to stain the cell nuclear (blue).
	SMAD3 Antibody (Center) (Cat. #P31307)immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of SMAD3 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.