Rabbit Polyclonal Antibody to SNAI1 (Ab-246)

包装: 1G|100G|500G|1KG|100KG

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别名:SNAH; SNAI; Sna; Snail; zinc finger protein SNAI1
应用:WB
反应种属:Human
规格：50μl/100μl

Description
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5′-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.Okubo T., Cancer Res. 61:1338-1346(2001).Twigg S.R., Hum. Genet. 105:320-326(1999).Paznekas W.A., Genomics 62:42-49(1999)

Description

Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5′-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.Okubo T., Cancer Res. 61:1338-1346(2001).Twigg S.R., Hum. Genet. 105:320-326(1999).Paznekas W.A., Genomics 62:42-49(1999)

Specification
Aliases	SNAH; SNAI; Sna; Snail; zinc finger protein SNAI1
Entrez GeneID	6615;
Swissprot	O95863
WB Predicted band size	29kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Synthesized non-phosphopeptide derived from human SNAI1 around the phosphorylation site of serine 246 (T-F-S(p)-R-M).
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.