Rabbit Polyclonal Antibody to Sodium Channel-pan

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别名:CIN5; HH1; SCN5A; Sodium channel protein; cardiac muscle alpha-subunit
应用:WB,IHC
反应种属:Human,Mouse,Rat
规格：50μl/100μl

Description
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 – 1427. T.R. Cummins, Neurology, Jan 2003; 60: 224 – 229. Christopher A. Ahern, Circ. Res., May 2005; 96: 991 – 998. Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 – 1310.

Description

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na+ channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels.Sebastian K.G. Maier, Circulation, Mar 2004; 109: 1421 – 1427. T.R. Cummins, Neurology, Jan 2003; 60: 224 – 229. Christopher A. Ahern, Circ. Res., May 2005; 96: 991 – 998. Jyoti Dhar Malhotra, Circulation, Mar 2001; 103: 1303 – 1310.

Specification
Aliases	CIN5; HH1; SCN5A; Sodium channel protein; cardiac muscle alpha-subunit
Entrez GeneID	6331;
Swissprot	Q14524
WB Predicted band size	230kDa
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthesized peptide derived from human sodium channel.
Formulation	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Application
WB	1/500-1/3000
IHC	1/50-1/100

	Western blot analysis of extracts from HuvEc cells, using Sodium Channel-pan antibody P41835.
	Immunohistochemical analysis of paraffin-embedded human heart tissue using Sodium Channel-pan antibody P41835.