中文 
别名:DKFZp686E07254; FLJ00340; FLJ34579; Lysp100b; nuclear antigen Sp100应用:WB
反应种属:Human
规格：50μl/100μl
| Description |
|---|
| Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to . Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to . Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.Dent A.L., Blood 88:1423-1426(1996).Seeler J.-S., Proc. Natl. Acad. Sci. U.S.A. 95:7316-7321(1998).Szostecki C., J. Immunol. 145:4338-4347(1990). |
| Specification | |
|---|---|
| Aliases | DKFZp686E07254; FLJ00340; FLJ34579; Lysp100b; nuclear antigen Sp100 |
| Entrez GeneID | 6672; |
| Swissprot | P23497 |
| WB Predicted band size | 100kDa |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from Internal of human SP100. |
| Formulation | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Application | |
|---|---|
| WB | 1/500-1/3000 |
 |
Western blot analysis of extracts from HT29 cells, using SP100 antibody P42502. |
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
暂无评论
本公司的所有产品仅用于科学研究或者工业应用等非医疗目的，不可用于人类或动物的临床诊断或治疗，非药用，非食用。
发表回复